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The generalizability of findings is also often limited by insufficient consideration of individual differences, such as genetic background, baseline nutritional status, gut microbiota composition, and specific OA phenotypes (e.g., metabolic vs

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In this model, liraglutide showed vascular protection by preventing the uncoupling of inducible nitric oxide synthase (iNOS) and reduced immune cell infiltration into the heart by decreasing levels of pro-inflammatory signals, namely, NF-B, TNF, and IL-1 [37]

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